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Terphenyllin suppresses the growth of Panc1 orthotopic tumors without producing any host toxicity. Panc1-Luc cells were being implanted orthotopically to the pancreas of SCID mice.Blend of bromodomain inhibitor JQ1 with MEK inhibitor PD-901 showed potent activity on killing PRC2-decline-perform and NF1 mutant malignant peripheral nerve sheath tumor